Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.51 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | CCNC | P24863 | 1/20 | 0.45 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7470175 | 0.92 | PIK3CD (0.50) | EGFRBRD4ERBB2ERBB4NTRK1 | |
| SCHEMBL9921372 | 0.87 | HTT (0.62) | EGFRBRD4ERBB2ERBB4MAPK1 | |
| SCHEMBL7461677 | 0.81 | HTR1A (0.46) | EGFRBRD4ERBB2ERBB4NTRK1 | |
| SCHEMBL7474806 | 0.80 | EGFR (0.52) | EGFRBRD4ERBB2ERBB4NTRK1 | |
| SCHEMBL7468656 | 0.80 | HTT (0.67) | EGFRERBB2NTRK1MAPK1KMT2A | |
| SCHEMBL7464247 | 0.77 | HTT (0.74) | NTRK1MAPK1KMT2AHTTAURKA | |
| SCHEMBL8498737 | 0.76 | EGFR (0.59) | EGFRBRD4ERBB2ERBB4MAPK1 | |
| SCHEMBL8482940 | 0.76 | MEN1 (0.77) | EGFRMAPK1KMT2AHTTLMNA | |
| SCHEMBL9921375 | 0.76 | HTT (0.65) | EGFRBRD4ERBB2ERBB4MAPK1 | |
| SCHEMBL5428633 | 0.75 | TRPV1 (0.58) | EGFRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229025-A1 | NOVEL QUINAZOLINE DERIVATIVES | Japan Energy Corporation (JP) | 2002-08-07 | — | — | EP | disclosed |