Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC10A2 | Q12908 | 3/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472192 | 1.00 | SLC10A2 (0.33) | SLC10A2MAPK10MAPK1TDP1CHRM1 | |
| SCHEMBL19170232 | 0.92 | CDK4 (0.32) | SLC10A2MAPK10 | |
| SCHEMBL2589094 | 0.89 | MAOA (0.37) | KDM4E | |
| SCHEMBL2589232 | 0.89 | SLC10A2 (0.33) | SLC10A2KDM4EALDH1A1 | |
| SCHEMBL17506154 | 0.89 | DRD2 (0.32) | SLC10A2 | |
| SCHEMBL17506155 | 0.89 | DRD2 (0.32) | SLC10A2 | |
| SCHEMBL2585237 | 0.88 | MAPK1 (0.32) | MAPK10MAPK1TDP1CHRM1 | |
| SCHEMBL7469254 | 0.86 | EGFR (0.40) | SLC10A2CHRM1KDM4E | |
| SCHEMBL7463854 | 0.86 | EGFR (0.40) | SLC10A2CHRM1KDM4E | |
| SCHEMBL2589896 | 0.86 | MAPK1 (0.35) | SLC10A2MAPK1TDP1CHRM1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775126-B1 | HYPOLIPIDEMIC 1,4-BENZOTHIAZEPINE-1,1-DIOXIDES | WELLCOME FOUND (GB) | 2002-10-30 | — | — | EP | disclosed |
| EP-1203769-A1 | Hypolipidemic 1,4-benzothiazepine derivative | THE WELLCOME FOUNDATION LIMITED (GB) | 2002-05-08 | — | — | EP | disclosed |
| CN-1059673-C | Hypolipidemic 1, 4-benzazepine * -1, 1-dioxides | WELLCOME FOUND (GB) | 2000-12-20 | — | — | CN | disclosed |
| US-5910494-A | NOVEL COMPOUNDS THAT REDUCE THE ABSORPTION OF BILE ACIDS FROM THE INTESTINE; FOR PROPHYLAXIS AND TREATMENT OF HYPERLIPIDEMIC CONDITIONS, SUCH AS ATHEROSCLEROSIS | GLAXO WELLCOME INC. (US) | 1999-06-08 | — | — | US | disclosed |
| CN-1161035-A | Hypolipidemic 1,4-benzothiazepine-1,1-dioxides | WELLCOME FOUND (GB) | 1997-10-01 | — | — | CN | disclosed |