Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR34 | Q9UPC5 | 2/20 | 0.66 |
| ▸ | MMP2 | P08253 | 11/20 | 0.62 |
| ▸ | MMP9 | P14780 | 6/20 | 0.62 |
| ▸ | ADAMTS4 | O75173 | 5/20 | 0.62 |
| ▸ | AR | P10275 | 1/20 | 0.61 |
| ▸ | MMP13 | P45452 | 4/20 | 0.58 |
| ▸ | MMP14 | P50281 | 2/20 | 0.58 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.57 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.57 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | MMP1 | P03956 | 1/20 | 0.57 |
| ▸ | MMP3 | P08254 | 1/20 | 0.57 |
| ▸ | MMP7 | P09237 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7470160 | 1.00 | GPR34 (0.66) | GPR34MMP2MMP9ADAMTS4AR | |
| SCHEMBL6037683 | 0.92 | MMP2 (0.66) | MMP2MMP9ADAMTS4MMP13MMP14 | |
| SCHEMBL6037682 | 0.92 | MMP2 (0.66) | MMP2MMP9ADAMTS4MMP13MMP14 | |
| SCHEMBL7468716 | 0.88 | MMP2 (0.79) | MMP2MMP9ADAMTS4MMP13ADAMTS5 | |
| SCHEMBL7460419 | 0.88 | MMP2 (0.79) | MMP2MMP9ADAMTS4MMP13ADAMTS5 | |
| SCHEMBL5189189 | 0.88 | MMP2 (0.79) | MMP2MMP9ADAMTS4MMP13ADAMTS5 | |
| SCHEMBL14602239 | 0.86 | MMP2 (0.79) | GPR34MMP2MMP9ADAMTS4AR | |
| SCHEMBL8385428 | 0.86 | ITGB3 (0.61) | GPR34MMP2MMP9ADAMTS4MMP13 | |
| SCHEMBL8652246 | 0.86 | ITGB3 (0.61) | GPR34MMP2MMP9ADAMTS4MMP13 | |
| SCHEMBL27540161 | 0.84 | MMP2 (0.57) | MMP2MMP9ADAMTS4MMP13MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874836-B1 | SULFONAMIDE INHIBITORS OF MATRIX METALLOPROTEINASES | WARNER LAMBERT CO (US) | 2002-10-09 | — | — | EP | disclosed |
| US-6297247-B1 | Sulfonamide inhibitors of matrix metalloproteinases | WARNER-LAMBERT COMPANY | 2001-10-02 | — | — | US | disclosed |
| US-6153612-A | Sulfonamide inhibitors of matrix metalloproteinases | WARNER-LAMBERT COMPANY (US) | 2000-11-28 | — | — | US | disclosed |
| US-5977141-A | Sulfonamide inhibitors of matrix metalloproteinases | WARNER-LAMBERT COMPANY (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0874836-A1 | SULFONAMIDE INHIBITORS OF MATRIX METALLOPROTEINASES | WARNER-LAMBERT COMPANY (US) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997019068-A1 | SULFONAMIDE INHIBITORS OF MATRIX METALLOPROTEINASES | WARNER-LAMBERT COMPANY (US) | 1997-05-29 | — | — | WO | disclosed |