SCHEMBL7470227

SCHEMBL7470227

CCON=C(C(C)=C(ON)c1ccccc1C(=COC)C(=O)OC)c1ccc(OCc2ccc(Cl)cc2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 1/20 0.42
MAOA P21397 4/20 0.41
MAOB P27338 4/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
SMN1; SMN2 Q16637 2/20 0.39
KDM4E B2RXH2 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
NR4A2 P43354 1/20 0.37
MEN1 O00255 1/20 0.36
POLB P06746 1/20 0.36
MAPK1 P28482 1/20 0.36
KMT2A Q03164 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
PKM P14618 1/20 0.35
BCL2L1 Q07817 1/20 0.35
MCL1 Q07820 1/20 0.35
HTT P42858 1/20 0.35
PPARA Q07869 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7467521 0.93 MAOB (0.40) HIF1AMAOAMAOBNPC1RAB9A
SCHEMBL7463037 0.91 SMN1; SMN2 (0.38) HIF1ANPC1RAB9ASMN1; SMN2KDM4E
SCHEMBL7465135 0.91 MAOB (0.43) HIF1AMAOBRAB9APOLBPPARA
SCHEMBL7742091 0.86 MAOB (0.47) HIF1AMAOBL3MBTL1NR4A2HTT
SCHEMBL7465788 0.86 MAOB (0.47) HIF1AMAOBL3MBTL1NR4A2HTT
SCHEMBL8541846 0.84 MAOB (0.38) MAOAMAOBNPC1RAB9ANR4A2
SCHEMBL7469591 0.84 RAB9A (0.31) NPC1RAB9ASMN1; SMN2KDM4ETDP1
SCHEMBL7469946 0.83 ALDH1A1 (0.35) SMN1; SMN2KDM4ETDP1L3MBTL1BCL2L1
SCHEMBL7470221 0.83 HIF1A (0.49) HIF1AMAOAMAOBNPC1RAB9A
SCHEMBL7470224 0.83 HIF1A (0.49) HIF1AMAOAMAOBNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0865424-B1 PESTICIDES BAYER AG (DE) 2002-09-18 EP disclosed
EP-0865424-A1 PESTICIDES Novartis AG (CH) 1998-09-23 EP disclosed
WO-1997020809-A1 PESTICIDES NOVARTIS AG (CH) 1997-06-12 WO disclosed