Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3115953 | 0.84 | ALDH1A1 (0.51) | MAPTCYP2C9CYP2C19DRD3KCNH2 | |
| SCHEMBL7460973 | 0.82 | MGLL (0.40) | MAPTCYP2C9CYP2C19DRD2DRD3 | |
| SCHEMBL7462955 | 0.82 | MEN1 (0.56) | MAPTCYP2C19ALDH1A1KMT2AHTT | |
| SCHEMBL7463285 | 0.78 | HDAC1 (0.47) | MAPTCYP2C9CYP2C19ALDH1A1KMT2A | |
| SCHEMBL7469357 | 0.75 | KCNN4 (0.47) | — | |
| SCHEMBL26357044 | 0.72 | MAPT (1.00) | MAPTCYP2C9CYP2C19DRD2DRD3 | |
| SCHEMBL8360734 | 0.72 | CYP2C9 (0.55) | MAPTCYP2C9CYP2C19DRD2DRD3 | |
| SCHEMBL2029640 | 0.71 | MEN1 (0.64) | MAPTCYP2C9CYP2C19DRD2DRD3 | |
| SCHEMBL7454344 | 0.70 | DRD2 (0.62) | MAPTCYP2C9CYP2C19DRD2DRD3 | |
| SCHEMBL5455104 | 0.70 | GSK3A (0.71) | MAPTCYP2C9CYP2C19SIGMAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214305-A1 | BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION | Maxia Pharmaceuticals, Inc. (US) | 2002-06-19 | — | — | EP | claimed |
| WO-2001016123-A1 | BENZYLIDENE-THIAZOLIDINEDIONES AND ANALOGUES AND THEIR USE IN THE TREATMENT OF INFLAMMATION | MAXIA PHARMACEUTICALS, INC. (US) | 2001-03-08 | — | — | WO | claimed |