Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8310167 | 0.81 | PDE5A (0.39) | PDE5APDE4DPDE7APDE1APDE1B | |
| SCHEMBL7470775 | 0.76 | ATM (0.49) | — | |
| SCHEMBL7458470 | 0.74 | DRD2 (0.48) | — | |
| SCHEMBL7207588 | 0.73 | SLC6A9 (0.32) | — | |
| SCHEMBL7470200 | 0.68 | POLB (0.45) | — | |
| SCHEMBL7475432 | 0.67 | DRD2 (0.68) | — | |
| SCHEMBL7457321 | 0.66 | DRD2 (0.49) | — | |
| SCHEMBL7478885 | 0.65 | DRD2 (0.54) | — | |
| SCHEMBL14507273 | 0.65 | — | — | |
| SCHEMBL7476726 | 0.65 | DRD2 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923576-A1 | 4-AMINOETHOXY-INDOLONE DERIVATIVES AS DOPAMINE D2 AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-06-23 | — | — | EP | claimed |
| WO-1998008843-A1 | 4-AMINOETHOXY-INDOLONE DERIVATIVES AS DOPAMINE D2 AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-03-05 | — | — | WO | claimed |