Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 5/20 | 0.50 |
| ▸ | SRC | P12931 | 3/20 | 0.50 |
| ▸ | CDK2 | P24941 | 3/20 | 0.50 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 3/20 | 0.44 |
| ▸ | BCR | P11274 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7470877 | 0.84 | CDK2 (0.70) | SYKSRCCDK2ZAP70MEN1 | |
| SCHEMBL7467043 | 0.81 | ABL1 (0.67) | SRCCDK5CDK5R1ABL1BCR | |
| SCHEMBL7468142 | 0.81 | PIK3CG (0.67) | SYKSRCCDK2ZAP70MEN1 | |
| SCHEMBL7471621 | 0.81 | MEN1 (0.59) | SYKCDK2MEN1KMT2AALDH1A1 | |
| SCHEMBL7464559 | 0.80 | IKBKB (0.53) | SYKSRCCDK2ZAP70CDK5 | |
| SCHEMBL7468137 | 0.79 | ABL1 (0.60) | SYKCDK2CDK5CDK5R1CDK4 | |
| SCHEMBL7475231 | 0.79 | SYK (0.66) | SYKSRCCDK2ZAP70MEN1 | |
| SCHEMBL7471212 | 0.77 | CDK5 (0.47) | SYKSRCCDK2ZAP70CDK5 | |
| SCHEMBL7528647 | 0.77 | ABL1 (0.72) | SRCZAP70ABL1BCRPDGFRB | |
| SCHEMBL14216069 | 0.77 | CDK2 (0.65) | SYKSRCCDK2ZAP70CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |