Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB known ✓ | P09619 | 5/20 | 0.67 |
| ▸ | ABL1 | P00519 | 16/20 | 0.86 |
| ▸ | PRKCA | P17252 | 8/20 | 0.86 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.86 |
| ▸ | EGFR | P00533 | 4/20 | 0.86 |
| ▸ | BCR | P11274 | 15/20 | 0.67 |
| ▸ | SRC | P12931 | 8/20 | 0.67 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.67 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.67 |
| ▸ | PRKCG | P05129 | 1/20 | 0.67 |
| ▸ | PRKCB | P05771 | 1/20 | 0.67 |
| ▸ | PRKCH | P24723 | 1/20 | 0.67 |
| ▸ | PRKCI | P41743 | 1/20 | 0.67 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.67 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.67 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.67 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.67 |
| ▸ | PRKACA | P17612 | 1/20 | 0.63 |
| ▸ | PRKACG | P22612 | 1/20 | 0.63 |
| ▸ | PRKACB | P22694 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6262145 | 0.93 | ABL1 (1.00) | ABL1PRKCAPRKCDEGFRBCR | |
| SCHEMBL29618427 | 0.86 | ABL1 (0.85) | ABL1PRKCAPRKCDEGFRBCR | |
| SCHEMBL4903275 | 0.84 | ABL1 (0.81) | ABL1PRKCAPRKCDEGFRBCR | |
| SCHEMBL7464205 | 0.83 | ABL1 (0.76) | ABL1PRKCAPRKCDEGFRBCR | |
| SCHEMBL210190 | 0.83 | ABL1 (0.76) | ABL1PRKCAPRKCDEGFRBCR | |
| SCHEMBL1593016 | 0.82 | PRKCD (0.79) | ABL1PRKCAPRKCDEGFRBCR | |
| Hydrochloric Acid SCHEMBL7470853 | 0.82 | ABL1 (0.74) | ABL1PRKCAPRKCDEGFRBCR | |
| SCHEMBL9197 | 0.81 | ABL1 (1.00) | ABL1PRKCAPRKCDEGFRBCR | |
| SCHEMBL7461475 | 0.81 | ABL1 (0.76) | ABL1PRKCAPRKCDEGFRBCR | |
| SCHEMBL16932355 | 0.81 | ABL1 (0.76) | ABL1PRKCAPRKCDEGFRBCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-0233461-B1 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 1996-03-20 | — | — | EP | disclosed |