Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | CMA1 | P23946 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472990 | 0.80 | HSD11B1 (0.41) | HSD11B1ALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL7472214 | 0.77 | MMP2 (0.37) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7449485 | 0.76 | HSD11B1 (0.38) | HSD11B1ALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL7476991 | 0.74 | PSEN1 (0.35) | HSD11B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7469169 | 0.70 | ROCK2 (0.36) | HSD11B1CMA1ALDH1A1KMT2ANPC1 | |
| SCHEMBL7420571 | 0.63 | CA12 (0.61) | NPC1RAB9AGAA | |
| Benzylsulfonylbenzene SCHEMBL780337 | 0.62 | TSHR (0.68) | MMP2ALDH1A1KMT2AMAPTTSHR | |
| SCHEMBL22206479 | 0.62 | BACE1 (0.46) | ALDH1A1MAPT | |
| SCHEMBL7441792 | 0.61 | DDB1 (0.49) | HSD11B1ALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL28942364 | 0.61 | HSD11B1 (0.59) | HSD11B1ALDH1A1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0739338-B1 | SERINE PROTEASE INHIBITORS: DERIVATIVES OF ISOTHIAZOLIDIN-3-ONE-1,1 DIOXIDE AND 3-OXO-1,2,5-THIADIAZOLIDINE-1,1-DIOXIDE | UNIV WICHITA STATE (US) | 2002-04-10 | — | — | EP | disclosed |
| US-5550139-A | ANTIINFLAMMATORY AGENT, ANTITUMOR AGENT, ANTICARCINOGENIC AGENT | THE WICHITA STATE UNIVERSITY (US) | 1996-08-27 | — | — | US | disclosed |