Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7471677 | 0.80 | HSD11B1 (0.38) | HSD11B1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL7449485 | 0.80 | HSD11B1 (0.38) | HSD11B1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL7469169 | 0.74 | ROCK2 (0.36) | HSD11B1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL7476991 | 0.73 | PSEN1 (0.35) | HSD11B1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL7473383 | 0.73 | HSD11B1 (0.34) | HSD11B1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL7462751 | 0.70 | GAA (0.41) | ALDH1A1LMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7464643 | 0.69 | GFER (0.41) | KMT2ALMNACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7472214 | 0.68 | MMP2 (0.37) | HSD11B1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL7434618 | 0.68 | HSD11B1 (0.44) | HSD11B1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL7465763 | 0.68 | EP300 (0.44) | KMT2AALDH1A1LMNACYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0739338-B1 | SERINE PROTEASE INHIBITORS: DERIVATIVES OF ISOTHIAZOLIDIN-3-ONE-1,1 DIOXIDE AND 3-OXO-1,2,5-THIADIAZOLIDINE-1,1-DIOXIDE | UNIV WICHITA STATE (US) | 2002-04-10 | — | — | EP | disclosed |
| US-5550139-A | ANTIINFLAMMATORY AGENT, ANTITUMOR AGENT, ANTICARCINOGENIC AGENT | THE WICHITA STATE UNIVERSITY (US) | 1996-08-27 | — | — | US | disclosed |