Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 11/20 | 0.37 |
| ▸ | MMP13 | P45452 | 9/20 | 0.37 |
| ▸ | MMP3 | P08254 | 7/20 | 0.37 |
| ▸ | MMP1 | P03956 | 3/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.35 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 2/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.32 |
| ▸ | MMP15 | P51511 | 1/20 | 0.32 |
| ▸ | MMP16 | P51512 | 1/20 | 0.32 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7474091 | 0.85 | GRIK1 (0.46) | MMP2MMP13MMP3MMP1MMP9 | |
| SCHEMBL7475365 | 0.70 | MMP3 (0.45) | MMP2MMP3MMP1MMP9 | |
| SCHEMBL8603890 | 0.67 | CA2 (0.36) | MMP2MMP3MMP1MMP9GRIK1 | |
| SCHEMBL8603892 | 0.67 | CA2 (0.36) | MMP2MMP3MMP1MMP9GRIK1 | |
| SCHEMBL8057889 | 0.67 | CA2 (0.36) | MMP2MMP3MMP1MMP9GRIK1 | |
| SCHEMBL1912588 | 0.67 | MME (0.51) | CA2CA9CTSSCTSK | |
| SCHEMBL1912534 | 0.67 | MME (0.51) | CA2CA9CTSSCTSK | |
| SCHEMBL11994292 | 0.67 | MME (0.51) | CA2CA9CTSSCTSK | |
| SCHEMBL7041264 | 0.67 | PTPN11 (0.68) | PTPN11CTSSCTSKACACB | |
| SCHEMBL2876345 | 0.66 | CA2 (0.51) | CA2CA9CTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944587-B1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARM (GB) | 2002-03-20 | — | — | EP | disclosed |
| EP-0944587-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998024759-A1 | METALLOPROTEINASE INHIBITORS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1998-06-11 | — | — | WO | disclosed |