Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.56 |
| ▸ | RBP4 | P02753 | 1/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.52 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7470468 | 0.85 | ATR (0.56) | — | |
| SCHEMBL7476032 | 0.80 | HRH4 (0.62) | HRH4RBP4 | |
| SCHEMBL4322429 | 0.79 | HRH4 (0.60) | HRH4RBP4PDE10A | |
| Hydrochloric Acid SCHEMBL7470971 | 0.78 | HTR2B (0.46) | CHIA | |
| Hydrochloric Acid SCHEMBL7470958 | 0.78 | HTR2B (0.46) | CHIA | |
| SCHEMBL9201000 | 0.78 | RAB9A (0.54) | RBP4PDE10ACHIA | |
| SCHEMBL27544931 | 0.77 | CHIA (0.52) | CHIADRD3 | |
| Hydrochloric Acid SCHEMBL7464028 | 0.77 | RAB9A (0.53) | RBP4PDE10ACHIA | |
| SCHEMBL20827228 | 0.77 | HRH4 (0.66) | HRH4RBP4PDE10A | |
| SCHEMBL8917958 | 0.76 | ALDH1A1 (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0650476-B1 | PERIPHERAL VASODILATING AGENT CONTAINING N-ACYLATED 4-AMINO PIPERIDINE DERIVATIVES AS ACTIVE INGREDIENTS | OTSUKA PHARMA CO LTD (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6136826-A | AMINOPIPERIDINE COMPOUNDS SUBSTITUTED WITH ALKANOYL | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2000-10-24 | — | — | US | disclosed |
| US-5656642-A | Peripheral vasodilating agent containing piperidine derivative as active ingredient | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-12 | — | — | US | disclosed |
| WO-1994022826-A1 | PERIPHERAL VASODILATING AGENT CONTAINING N-ACYLATED 4-AMINO PIPERIDINE DERIVATIVES AS ACTIVE INGREDIENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-10-13 | — | — | WO | disclosed |