Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8920610 | 0.89 | ALDH1A1 (0.45) | ALDH1A1KDM4EPKMGLAPOLB | |
| Hydrochloric Acid SCHEMBL8921537 | 0.83 | PDE3B (0.53) | ALDH1A1SMN1; SMN2RAB9AHSD17B10 | |
| SCHEMBL8918884 | 0.79 | MAPK14 (0.51) | ALDH1A1KDM4EPKMGLAPOLB | |
| SCHEMBL8918938 | 0.79 | PDE3B (0.48) | POLBLMNARAB9ANPC1 | |
| SCHEMBL7476032 | 0.79 | HRH4 (0.62) | POLBSMN1; SMN2 | |
| SCHEMBL8918737 | 0.78 | SMN1; SMN2 (0.51) | KDM4EPKMSMN1; SMN2RAB9A | |
| Hydrochloric Acid SCHEMBL7471638 | 0.77 | MEN1 (0.46) | ALDH1A1SMN1; SMN2RAB9ANPC1HSD17B10 | |
| SCHEMBL8920344 | 0.76 | KMT2A (0.46) | ALDH1A1KDM4EPOLBLMNA | |
| SCHEMBL7472433 | 0.76 | HRH4 (0.56) | — | |
| SCHEMBL27544931 | 0.76 | CHIA (0.52) | ALDH1A1PKMPOLBOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5591751-A | CARBOSTYRIL DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-01-07 | — | — | US | disclosed |
| EP-0636128-A1 | PIPERAZINOCARBONYLCARBOSTYRILS AS PERIPHERAL VASODILATORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-02-01 | — | — | EP | disclosed |
| WO-1994019339-A1 | PIPERAZINOCARBONYLCARBOSTYRILS AS PERIPHERAL VASODILATORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-09-01 | — | — | WO | disclosed |