SCHEMBL7472677

SCHEMBL7472677

Clc1cc(-c2nnn[nH]2)n(-c2ccc(COc3ccnc4ccccc34)cc2)c1

nearest known ligand 0.48

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 1/20 0.36
PTGER1 P34995 1/20 0.34
LMNA P02545 1/20 0.34
MAPT P10636 1/20 0.34
HTT P42858 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
MET P08581 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7464057 0.84 AGTR1 (0.50)
SCHEMBL7467651 0.83 AGTR1 (0.43) LMNAMAPTHTTSMN1; SMN2L3MBTL1
SCHEMBL7467991 0.80 NR1H4 (0.38) RAB9APTGER1LMNAMAPTHTT
SCHEMBL7421729 0.78 RAB9A (0.39) RAB9ALMNAMAPTHTTSMN1; SMN2
Hydrochloric Acid SCHEMBL9182585 0.76 AGTR1 (0.45)
SCHEMBL9040678 0.74 MEN1 (0.46) MAPTHTTSMN1; SMN2
SCHEMBL7469162 0.70 POLB (0.36) LMNAMAPTHTTSMN1; SMN2L3MBTL1
SCHEMBL7471849 0.70 MEN1 (0.52) RAB9ALMNAMAPTHTTSMN1; SMN2
SCHEMBL9042834 0.69 AGTR1 (0.50) LMNAMAPT
SCHEMBL9431635 0.68 PLAU (0.50) LMNAMAPTHTTSMN1; SMN2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1993016071-A1 HETEROCYCLIC DERIVATIVES AS ANGIOTENSIN II ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1993-08-19 WO disclosed