Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.32 |
| ▸ | GLA | P06280 | 2/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | NPY1R | P25929 | 2/20 | 0.32 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.32 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | TOP1 | P11387 | 1/20 | 0.32 |
| ▸ | TOP2A | P11388 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7468982 | 0.79 | ALDH1A1 (0.45) | PIK3CDPIK3CAGLAPIK3CBPIK3CG | |
| SCHEMBL7467654 | 0.78 | NPY1R (0.37) | PIK3CDPIK3CAGLAPIK3CBPIK3CG | |
| SCHEMBL7466587 | 0.78 | CCR4 (0.36) | PIK3CDPIK3CAPIK3CBPIK3CGNPY1R | |
| SCHEMBL7476942 | 0.77 | ALDH1A1 (0.38) | PIK3CDPIK3CAPIK3CBPIK3CGTP53 | |
| SCHEMBL7468793 | 0.77 | CCR4 (0.36) | PIK3CDPIK3CAPIK3CBPIK3CGNPY1R | |
| SCHEMBL7475650 | 0.76 | CCR4 (0.35) | PIK3CDPIK3CAPIK3CBPIK3CGHSD17B10 | |
| SCHEMBL7475628 | 0.75 | NQO2 (0.33) | NQO2HSD17B10KMT2AKDM4EMEN1 | |
| SCHEMBL7465420 | 0.75 | SMN1; SMN2 (0.33) | PIK3CDPIK3CAGLAPIK3CBPIK3CG | |
| SCHEMBL7470948 | 0.74 | GLP1R (0.33) | PIK3CANPY1RHIF1AHSD17B10CCR4 | |
| SCHEMBL8935311 | 0.72 | SMN1; SMN2 (0.32) | PIK3CANPY1RHIF1ACCR4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783495-B1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER LTD (GB) | 2002-02-27 | — | — | EP | disclosed |
| US-5852016-A | Quinoxaline derivatives useful in therapy | PFIZER INC. (US) | 1998-12-22 | — | — | US | disclosed |
| EP-0783495-A1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | Pfizer Limited (GB) | 1997-07-16 | — | — | EP | disclosed |
| WO-1996009295-A1 | QUINOXALINE DERIVATIVES USEFUL IN THERAPY | PFIZER LIMITED (GB) | 1996-03-28 | — | — | WO | disclosed |