Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.67 |
| ▸ | PRKCA | P17252 | 2/20 | 0.67 |
| ▸ | EGFR | P00533 | 1/20 | 0.67 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.67 |
| ▸ | CAMK2D | Q13557 | 4/20 | 0.64 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.63 |
| ▸ | IKBKB | O14920 | 3/20 | 0.63 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.63 |
| ▸ | JAK2 | O60674 | 2/20 | 0.61 |
| ▸ | JAK3 | P52333 | 1/20 | 0.61 |
| ▸ | BCR | P11274 | 2/20 | 0.60 |
| ▸ | SRC | P12931 | 1/20 | 0.60 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.57 |
| ▸ | GSK3B | P49841 | 2/20 | 0.57 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.56 |
| ▸ | PLK1 | P53350 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4029958 | 0.92 | ABL1 (0.72) | ABL1PRKCAEGFRPRKCDCAMK2D | |
| SCHEMBL1593016 | 0.87 | PRKCD (0.79) | ABL1PRKCAEGFRPRKCDCAMK2D | |
| SCHEMBL709831 | 0.84 | IKBKB (0.59) | ABL1PRKCAEGFRPRKCDCAMK2D | |
| SCHEMBL7467852 | 0.83 | PIK3CA (0.65) | ABL1PRKCAEGFRPRKCDCAMK2D | |
| SCHEMBL4903317 | 0.83 | ABL1 (0.70) | ABL1PRKCAEGFRPRKCDCAMK2D | |
| SCHEMBL7470875 | 0.83 | PLK1 (0.63) | ABL1PRKCAEGFRPRKCDCAMK2D | |
| SCHEMBL7470313 | 0.83 | ABL1 (0.58) | ABL1PRKCAEGFRPRKCDCAMK2D | |
| Nitric Acid SCHEMBL10765821 | 0.82 | ABL1 (0.68) | ABL1PRKCAEGFRPRKCDCAMK2D | |
| Nitric Acid SCHEMBL10765825 | 0.82 | ABL1 (0.68) | ABL1PRKCAEGFRPRKCDCAMK2D | |
| SCHEMBL4903404 | 0.82 | JAK2 (0.68) | ABL1PRKCAEGFRPRKCDCAMK2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |