Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7171239 | 0.84 | LTA4H (0.43) | KMT2AKDM4EMEN1 | |
| SCHEMBL1827943 | 0.79 | LTA4H (0.40) | SMN1; SMN2ALDH1A1KDM4EHPGDNPC1 | |
| SCHEMBL1829382 | 0.79 | LTA4H (0.39) | KMT2ASMN1; SMN2ALDH1A1KDM4EMEN1 | |
| SCHEMBL4719481 | 0.79 | SMN1; SMN2 (0.36) | KMT2ALMNASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL10344804 | 0.79 | SMN1; SMN2 (0.56) | KMT2ASMN1; SMN2POLBALDH1A1KDM4E | |
| SCHEMBL16695922 | 0.77 | MAPT (0.50) | KMT2ASMN1; SMN2POLBALDH1A1KDM4E | |
| SCHEMBL19121186 | 0.77 | L3MBTL1 (0.50) | KMT2ALMNASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL28643916 | 0.77 | CYP2D6 (0.41) | KMT2ALMNASMN1; SMN2ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL5223635 | 0.77 | LTA4H (0.38) | KMT2ASMN1; SMN2ALDH1A1KDM4EMEN1 | |
| SCHEMBL74752 | 0.77 | CYP2D6 (0.41) | KMT2ALMNASMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0950046-B1 | 3,4-DISUBSTITUTED AZETIDIN-2-ONE DERIVATIVES USEFUL AS CYSTEINE PROTEINASE REGULATORS | NAEJA PHARMACEUTICAL INC (CA) | 2002-04-10 | — | — | EP | claimed |
| CN-107949559-B | Bicyclic fused heteroaryl or aryl compounds as IRAK4 modulators | 辉瑞公司 | 2020-12-11 | — | — | CN | disclosed |