Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 11/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7489141 | 0.87 | CCR2 (0.60) | CCR2ABCB11 | |
| SCHEMBL7465471 | 0.87 | SRD5A2 (0.54) | CCR2ABCB11SRD5A2PLA2G4ALTB4R | |
| SCHEMBL7472885 | 0.86 | CCR2 (0.48) | CCR2ABCB11SRD5A2PLA2G4ALTB4R | |
| SCHEMBL7525789 | 0.85 | ABCB11 (0.49) | CCR2ABCB11SRD5A2PLA2G4AMCL1 | |
| SCHEMBL7455739 | 0.85 | CCR2 (0.57) | CCR2ABCB11SRD5A2PLA2G4ALTB4R | |
| SCHEMBL7466879 | 0.84 | EDNRB (0.48) | CCR2ABCB11SRD5A2PLA2G4AMCL1 | |
| SCHEMBL7468637 | 0.84 | CCR2 (0.47) | CCR2ABCB11SRD5A2PLA2G4AMCL1 | |
| SCHEMBL7462839 | 0.84 | CCR2 (0.46) | CCR2ABCB11ARSRD5A2PLA2G4A | |
| SCHEMBL7467129 | 0.83 | CCR2 (0.54) | CCR2SRD5A2 | |
| SCHEMBL7458022 | 0.82 | CCR2 (0.52) | CCR2ABCB11ARSRD5A2LTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6670388-B1 | Fatty acid synthase inhibitors | SMITHKLINE BEECHAM CORPORATION | 2003-12-30 | — | — | US | claimed |
| WO-2002000620-A1 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-01-03 | — | — | WO | claimed |
| US-6670388-B1 | Fatty acid synthase inhibitors | SMITHKLINE BEECHAM CORPORATION | 2003-12-30 | — | — | US | disclosed |
| WO-2002000620-A1 | FATTY ACID SYNTHASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-01-03 | — | — | WO | disclosed |