Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 17/20 | 0.48 |
| ▸ | KLK7 | P49862 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8209795 | 0.89 | HTR6 (0.49) | HTR6KLK7CYP3A4CYP2D6KDM1A | |
| SCHEMBL8208544 | 0.84 | HTR6 (0.44) | HTR6KLK7KDM1A | |
| SCHEMBL8483101 | 0.81 | HTR6 (0.43) | HTR6KLK7KDM1A | |
| SCHEMBL8208598 | 0.80 | HTR6 (0.48) | HTR6KDM1A | |
| SCHEMBL22632714 | 0.80 | HTR6 (0.54) | HTR6KLK7CYP3A4CYP2D6KDM1A | |
| SCHEMBL8209521 | 0.80 | HTR6 (0.51) | HTR6KDM1A | |
| SCHEMBL8200945 | 0.80 | HTR6 (0.47) | HTR6KLK7 | |
| SCHEMBL8208533 | 0.79 | HTR6 (0.57) | HTR6 | |
| SCHEMBL8201582 | 0.79 | HTR6 (0.50) | HTR6CYP3A4CYP2D6KDM1A | |
| SCHEMBL7484423 | 0.78 | HTR6 (0.39) | HTR6KLK7KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975594-B1 | PROCESS FOR THE PRODUCTION OF INDOLE DERIVATIVES | PFIZER LTD (GB) | 2002-09-18 | — | — | EP | disclosed |
| US-6281357-B1 | HEADACHE THERAPY | PFIZER INC | 2001-08-28 | — | — | US | disclosed |
| EP-0975594-A1 | PROCESS FOR THE PRODUCTION OF INDOLE DERIVATIVES | Pfizer Limited (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1999002493-A1 | PROCESS FOR THE PRODUCTION OF INDOLE DERIVATIVES | PFIZER LIMITED (GB) | 1999-01-21 | — | — | WO | disclosed |