Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 18/20 | 0.49 |
| ▸ | KLK7 | P49862 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472995 | 0.89 | HTR6 (0.48) | HTR6KLK7CYP3A4CYP2D6KDM1A | |
| SCHEMBL8208598 | 0.88 | HTR6 (0.48) | HTR6KDM1A | |
| SCHEMBL8201528 | 0.85 | HTR6 (0.50) | HTR6CYP3A4CYP2D6 | |
| SCHEMBL8208544 | 0.84 | HTR6 (0.44) | HTR6KLK7KDM1A | |
| SCHEMBL8483101 | 0.81 | HTR6 (0.43) | HTR6KLK7KDM1A | |
| SCHEMBL8209521 | 0.80 | HTR6 (0.51) | HTR6KDM1A | |
| SCHEMBL8200945 | 0.80 | HTR6 (0.47) | HTR6KLK7 | |
| SCHEMBL8201606 | 0.79 | HTR6 (0.45) | HTR6 | |
| SCHEMBL8208533 | 0.79 | HTR6 (0.57) | HTR6 | |
| SCHEMBL8201582 | 0.79 | HTR6 (0.50) | HTR6CYP3A4CYP2D6KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100291-A | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | ALLELIX BIOPHARMACEUTICALS INC. (CA) | 2000-08-08 | — | — | US | disclosed |
| WO-1999047516-A1 | 3-(2-PYRROLIDINYLMETHYL)-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY | SLASSI ABDELMALIK (CA) | 1999-09-23 | — | — | WO | disclosed |