Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | EP300 | Q09472 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7476991 | 0.76 | PSEN1 (0.35) | HSD11B1KMT2AALDH1A1MEN1MAPT | |
| SCHEMBL7472990 | 0.73 | HSD11B1 (0.41) | HSD11B1KMT2AALDH1A1MEN1MAPT | |
| SCHEMBL7449485 | 0.72 | HSD11B1 (0.38) | HSD11B1KMT2AALDH1A1MEN1MAPT | |
| SCHEMBL7471677 | 0.64 | HSD11B1 (0.38) | HSD11B1KMT2AALDH1A1MEN1MAPT | |
| SCHEMBL7472214 | 0.61 | MMP2 (0.37) | HSD11B1KMT2AALDH1A1MEN1NPC1 | |
| SCHEMBL22206479 | 0.59 | BACE1 (0.46) | ALDH1A1MAPT | |
| SCHEMBL7441792 | 0.58 | DDB1 (0.49) | HSD11B1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL7434618 | 0.58 | HSD11B1 (0.44) | HSD11B1KMT2AALDH1A1MEN1MAPT | |
| SCHEMBL29013938 | 0.58 | DDB1 (0.52) | HSD11B1KMT2AALDH1A1MEN1MAPT | |
| SCHEMBL5136681 | 0.57 | EP300 (0.44) | HSD11B1KMT2AALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0739338-B1 | SERINE PROTEASE INHIBITORS: DERIVATIVES OF ISOTHIAZOLIDIN-3-ONE-1,1 DIOXIDE AND 3-OXO-1,2,5-THIADIAZOLIDINE-1,1-DIOXIDE | UNIV WICHITA STATE (US) | 2002-04-10 | — | — | EP | disclosed |
| US-5550139-A | ANTIINFLAMMATORY AGENT, ANTITUMOR AGENT, ANTICARCINOGENIC AGENT | THE WICHITA STATE UNIVERSITY (US) | 1996-08-27 | — | — | US | disclosed |