Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.52 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.51 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.51 |
| ▸ | RORC | P51449 | 3/20 | 0.51 |
| ▸ | NAMPT | P43490 | 2/20 | 0.50 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7413756 | 0.90 | POLB (0.56) | POLBSAE1UBA2RORCPAX8 | |
| SCHEMBL3084650 | 0.90 | RORC (0.59) | POLBPGRSAE1UBA2RORC | |
| SCHEMBL9223532 | 0.84 | POLB (0.64) | POLBPGRSAE1UBA2RORC | |
| SCHEMBL15899425 | 0.84 | POLB (0.59) | POLBPGRSAE1UBA2RORC | |
| SCHEMBL7308833 | 0.83 | L3MBTL1 (0.58) | POLBPGRRORCMAPTHTT | |
| SCHEMBL8688893 | 0.83 | SAE1 (0.57) | POLBSAE1UBA2RORCPAX8 | |
| SCHEMBL23054844 | 0.83 | POLB (0.58) | POLBPGRSAE1UBA2RORC | |
| SCHEMBL15480399 | 0.83 | HDAC1 (0.65) | RORCPAX8HDAC3HDAC4HDAC1 | |
| SCHEMBL13716356 | 0.83 | RORC (0.53) | POLBPGRSAE1UBA2RORC | |
| SCHEMBL20777973 | 0.81 | PGR (0.65) | POLBPGRRORCNAMPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691953-B1 | 1-AMIDINOPHENYL-PYRROLIDONES/ PIPERIDINONES AS PLATELET AGGREGATION INHIBITORS | SEARLE & CO (US) | 2000-08-02 | — | — | EP | disclosed |
| US-5986107-A | Process for the preparation of a 2-oxopyrrolidine compound | G. D. SEARLE & CO. (US) | 1999-11-16 | — | — | US | disclosed |
| US-5721366-A | PHENYLAMIDINE DERIVATIVES | G. D. SEARLE & CO (US) | 1998-02-24 | — | — | US | disclosed |
| CN-1124957-A | 1-amidinophenyl-pyrrolidones piperidinones azetinones as platelet aggregation inhibitors | SEARLE & CO (US) | 1996-06-19 | — | — | CN | disclosed |
| EP-0691953-A1 | 1-AMIDINOPHENYL-PYRROLIDONES PIPERIDINONES AZETINONES AS PLATELET AGGREGATION INHIBITORS | G.D. SEARLE & CO. (US) | 1996-01-17 | — | — | EP | disclosed |
| WO-1994022820-A1 | 1-AMIDINOPHENYL-PYRROLIDONES PIPERIDINONES AZETINONES AS PLATELET AGGREGATION INHIBITORS | G.D. SEARLE & CO. (US) | 1994-10-13 | — | — | WO | disclosed |