Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | RORC | P51449 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | PTPRC | P08575 | 3/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8407366 | 0.96 | L3MBTL1 (0.54) | L3MBTL1RORCALDH1A1HTTHPGD | |
| SCHEMBL3084650 | 0.89 | RORC (0.59) | L3MBTL1RORCALDH1A1HTTPOLB | |
| SCHEMBL8410410 | 0.87 | ALDH1A1 (0.60) | L3MBTL1RORCALDH1A1HTTHPGD | |
| SCHEMBL878909 | 0.84 | KMT2A (0.53) | ALDH1A1HTTHPGDPOLBMEN1 | |
| SCHEMBL9223532 | 0.83 | POLB (0.64) | L3MBTL1RORCALDH1A1HTTHPGD | |
| SCHEMBL7473435 | 0.83 | POLB (0.53) | RORCALDH1A1HTTPOLBHDAC8 | |
| SCHEMBL31635262 | 0.82 | L3MBTL1 (0.69) | L3MBTL1ALDH1A1HTTHPGDHDAC8 | |
| SCHEMBL20777973 | 0.81 | PGR (0.65) | L3MBTL1RORCHTTHPGDPOLB | |
| SCHEMBL15480393 | 0.81 | PGR (0.65) | L3MBTL1RORCHTTHPGDPOLB | |
| SCHEMBL1355675 | 0.80 | L3MBTL1 (0.58) | L3MBTL1ALDH1A1HTTHPGDHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445796-B1 | Derivatives of acetic acid containing peptide bonds | HOFFMANN LA ROCHE (CH) | 1998-06-17 | — | — | EP | disclosed |
| US-5430024-A | Peptides bearing N-terminal amidino moieties and their use as inhibitors of platelet aggregation | HOFFMANN-LA ROCHE INC. (US) | 1995-07-04 | — | — | US | disclosed |
| US-5273982-A | An amidinoaryleneamidoalkylpiperazinyleneacetic acid | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0445796-A2 | Derivatives of acetic acid | F. HOFFMANN-LA ROCHE AG (CH) | 1991-09-11 | — | — | EP | disclosed |