Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.50 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | SNCA | P37840 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | CASP4 | P49662 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | CASP9 | P55211 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7468750 | 0.90 | CASP3 (0.44) | SIRT2SIRT1ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL7472270 | 0.88 | ALDH1A1 (0.55) | SIRT2SIRT1ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL7474357 | 0.88 | CASP1 (0.53) | SIRT2SIRT1ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL7476860 | 0.85 | TSHR (0.64) | ALDH1A1SMN1; SMN2TSHRKMT2AHTT | |
| SCHEMBL7473291 | 0.84 | TSHR (0.54) | ALDH1A1SMN1; SMN2TSHRKMT2AHTT | |
| SCHEMBL7472920 | 0.83 | TSHR (0.56) | ALDH1A1SMN1; SMN2TSHRKMT2AHTT | |
| SCHEMBL7470312 | 0.83 | ALDH1A1 (0.48) | SIRT2SIRT1ALDH1A1TSHRKMT2A | |
| SCHEMBL7472359 | 0.81 | CASP1 (0.43) | SIRT2SIRT1ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL189949 | 0.81 | MAPT (0.44) | ALDH1A1SMN1; SMN2TSHRKMT2AAPP | |
| SCHEMBL7472305 | 0.81 | TSHR (0.53) | ALDH1A1SMN1; SMN2TSHRKMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869949-B1 | BENZOXAZINE ANTIMICROBIAL AGENTS | ORTHO MCNEIL PHARM INC (US) | 2002-12-18 | — | — | EP | disclosed |
| US-5854242-A | Benzoxazine antimicrobial agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1998-12-29 | — | — | US | disclosed |
| EP-0869949-A1 | BENZOXAZINE ANTIMICROBIAL AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1998-10-14 | — | — | EP | disclosed |
| US-5696117-A | BACTERICIDE | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-12-09 | — | — | US | disclosed |
| WO-1997017333-A1 | BENZOXAZINE ANTIMICROBIAL AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-05-15 | — | — | WO | disclosed |