Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 2/20 | 0.34 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 4/20 | 0.33 |
| ▸ | IKBKB | O14920 | 3/20 | 0.33 |
| ▸ | PRKACA | P17612 | 2/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7471882 | 0.74 | GAA (0.33) | GAAALDH1A1HPGD | |
| SCHEMBL20212134 | 0.71 | GAA (0.45) | GAAALDH1A1HSD17B10HPGDALOX15 | |
| SCHEMBL8052245 | 0.70 | GAA (0.48) | GAAALDH1A1HSD17B10HPGDALOX15 | |
| SCHEMBL5988926 | 0.68 | GAA (1.00) | GAAALDH1A1HSD17B10HPGDALOX15 | |
| Hydrochloric Acid SCHEMBL5987101 | 0.68 | GAA (0.47) | GAAALDH1A1HSD17B10HPGDALOX15 | |
| SCHEMBL16172596 | 0.67 | GPR35 (0.46) | GAAALDH1A1HSD17B10HPGDALOX15 | |
| SCHEMBL2808132 | 0.64 | GPR35 (0.52) | GAAALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL15210799 | 0.64 | LIMK1 (0.40) | GAAALDH1A1HSD17B10HPGDALOX15 | |
| SCHEMBL22601411 | 0.64 | ALDH1A1 (0.49) | GAAALDH1A1HSD17B10HPGDALOX15 | |
| SCHEMBL21548186 | 0.63 | ALDH1A1 (0.47) | GAAALDH1A1HSD17B10HPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054886-B1 | HETEROARYL AMIDINES, METHYLAMIDINES AND GUANIDINES AS PROTEASE INHIBITORS, IN PARTICULAR AS UROKINASE INHIBITORS | DIMENSIONAL PHARM INC (US) | 2002-09-04 | — | — | EP | claimed |
| EP-1054886-B1 | HETEROARYL AMIDINES, METHYLAMIDINES AND GUANIDINES AS PROTEASE INHIBITORS, IN PARTICULAR AS UROKINASE INHIBITORS | DIMENSIONAL PHARM INC (US) | 2002-09-04 | — | — | EP | disclosed |