Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7475609 | 0.87 | ALDH1A1 (0.61) | HTTL3MBTL1SIGMAR1HTR6ALDH1A1 | |
| SCHEMBL7532954 | 0.87 | ALDH1A1 (0.61) | HTTL3MBTL1SIGMAR1HTR6ALDH1A1 | |
| SCHEMBL7532960 | 0.87 | ALDH1A1 (0.61) | HTTL3MBTL1SIGMAR1HTR6ALDH1A1 | |
| SCHEMBL7534695 | 0.80 | HTR6 (0.48) | HTTL3MBTL1SIGMAR1HTR6ALDH1A1 | |
| SCHEMBL7467872 | 0.79 | EIF2AK2 (0.55) | HTTL3MBTL1ALDH1A1LMNAGAA | |
| SCHEMBL7480479 | 0.79 | NCF1 (0.62) | HTR6ALDH1A1NCF1 | |
| SCHEMBL3947283 | 0.79 | HTR6 (0.46) | HTTSIGMAR1HTR6PARP1KMT2A | |
| SCHEMBL7531418 | 0.78 | HTR6 (0.51) | L3MBTL1HTR6ALDH1A1LMNAPARP1 | |
| SCHEMBL7531412 | 0.78 | HTR6 (0.51) | L3MBTL1HTR6ALDH1A1LMNAPARP1 | |
| SCHEMBL16549301 | 0.77 | ALDH1A1 (0.57) | HTTALDH1A1LMNASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228066-A2 | SULFONAMIDE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001032646-A2 | SULFONAMIDE DERIVATIVES | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-05-10 | — | — | WO | disclosed |