Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NCF1 | P14598 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7532960 | 1.00 | ALDH1A1 (0.61) | ALDH1A1LMNAHTR6HTR1AHTR1D | |
| SCHEMBL7532954 | 1.00 | ALDH1A1 (0.61) | ALDH1A1LMNAHTR6HTR1AHTR1D | |
| SCHEMBL7531412 | 0.88 | HTR6 (0.51) | ALDH1A1LMNAHTR6NCF1L3MBTL1 | |
| SCHEMBL7531418 | 0.88 | HTR6 (0.51) | ALDH1A1LMNAHTR6NCF1L3MBTL1 | |
| SCHEMBL7474130 | 0.87 | HTT (0.59) | ALDH1A1LMNAHTR6HTTNCF1 | |
| SCHEMBL7480479 | 0.83 | NCF1 (0.62) | ALDH1A1HTR6HTR1AHTR1DHTR1B | |
| SCHEMBL7534695 | 0.81 | HTR6 (0.48) | ALDH1A1LMNAHTR6HTTL3MBTL1 | |
| SCHEMBL4041944 | 0.80 | HTR6 (0.49) | ALDH1A1LMNAHTR6HTR1AHTR1D | |
| SCHEMBL4132251 | 0.80 | HTR6 (0.49) | ALDH1A1LMNAHTR6HTR1AHTR1D | |
| SCHEMBL7467872 | 0.79 | EIF2AK2 (0.55) | ALDH1A1LMNAHTTL3MBTL1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228066-A2 | SULFONAMIDE DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001032646-A2 | SULFONAMIDE DERIVATIVES | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-05-10 | — | — | WO | disclosed |