Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7480610 | 0.82 | ALDH1A1 (0.31) | RAB9AALDH1A1 | |
| SCHEMBL7480607 | 0.82 | ALDH1A1 (0.31) | RAB9AALDH1A1 | |
| SCHEMBL7479670 | 0.81 | MEN1 (0.36) | RAB9ACYP3A4MEN1KMT2AALDH1A1 | |
| SCHEMBL7477896 | 0.80 | MEN1 (0.33) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL7487012 | 0.79 | KDM4E (0.37) | MEN1KMT2AALDH1A1 | |
| SCHEMBL7478235 | 0.79 | ADORA2B (0.31) | MEN1KMT2A | |
| SCHEMBL7482378 | 0.78 | ALDH1A1 (0.37) | CYP3A4MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL7475018 | 0.78 | KDM4E (0.32) | RAB9ACYP3A4ALDH1A1LMNAMAPT | |
| SCHEMBL7478519 | 0.77 | ALDH1A1 (0.33) | RAB9AALDH1A1LMNAMAPTNPSR1 | |
| SCHEMBL7478089 | 0.77 | KDM4E (0.32) | ALDH1A1LMNAMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0742218-B1 | PYRROLOPYRIDAZINE DERIVATIVE | SANKYO CO (JP) | 2002-12-04 | — | — | EP | disclosed |
| US-6063782-A | Pyrrolopyridazine derivatives | SANKYO COMPANY, LIMITED (JP) | 2000-05-16 | — | — | US | disclosed |
| EP-0742218-A1 | PYRROLOPYRIDAZINE DERIVATIVE | SANKYO COMPANY LIMITED (JP) | 1996-11-13 | — | — | EP | disclosed |