Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7475318 | 0.86 | MAPK14 (0.42) | MAPK14CDK5CDK5R1POLBGAA | |
| SCHEMBL7473148 | 0.84 | MAPK14 (0.44) | MAPK14POLBGAANPC1TSHR | |
| SCHEMBL7471841 | 0.84 | MAPK14 (0.44) | MAPK14POLBHTTGAANPC1 | |
| SCHEMBL7470949 | 0.81 | KDM4E (0.49) | MAPK14POLBGAATSHRKDM4E | |
| SCHEMBL7471290 | 0.81 | ALDH1A1 (0.41) | MAPK14CDK5CDK5R1CES2CES1 | |
| SCHEMBL7475041 | 0.80 | F7 (0.42) | POLBCCNA2CDK2GAANPC1 | |
| SCHEMBL7471362 | 0.79 | LTA4H (0.40) | MAPK14HTTNPC1SMN1; SMN2RAB9A | |
| SCHEMBL7475152 | 0.78 | MAPK14 (0.44) | MAPK14POLBHTTGAANPC1 | |
| SCHEMBL7468553 | 0.76 | MAPK14 (0.45) | MAPK14CDK2HTTGAAMEN1 | |
| SCHEMBL7469629 | 0.76 | KMT2A (0.44) | CES2CES1NPC1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077701-A4 | ANTI-VIRAL COMPOUNDS | LILLY CO ELI (US) | 2002-03-20 | — | — | EP | disclosed |
| EP-1077701-A1 | ANTI-VIRAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059587-A1 | ANTI-VIRAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 1999-11-25 | — | — | WO | disclosed |