Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 6/20 | 0.62 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.48 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.48 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7469664 | 0.91 | HTT (0.63) | HTTNR2F2EGFRTTBK1TTBK2 | |
| SCHEMBL7469795 | 0.90 | EGFR (0.60) | HTTNR2F2EGFRPDE5ANTRK1 | |
| SCHEMBL7475626 | 0.89 | HTT (0.52) | HTTNR2F2EGFRPDE5ANTRK1 | |
| SCHEMBL7464363 | 0.89 | HTT (0.54) | HTTNR2F2EGFRPDE5ANTRK1 | |
| SCHEMBL7474181 | 0.89 | MAPK1 (0.56) | HTTNR2F2RAB9AEGFRCNR1 | |
| SCHEMBL7473897 | 0.89 | EGFR (0.55) | HTTNR2F2EGFRMAPK1ALK | |
| SCHEMBL7528662 | 0.88 | EGFR (0.52) | HTTNR2F2RAB9AEGFRPDE5A | |
| SCHEMBL7465161 | 0.87 | PDE5A (0.52) | HTTEGFRPDE5AMEN1KMT2A | |
| SCHEMBL7462734 | 0.84 | EGFR (0.55) | HTTNR2F2EGFRNTRK1CNR1 | |
| SCHEMBL7463417 | 0.83 | EGFR (0.49) | HTTNR2F2EGFRNTRK1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229025-A1 | NOVEL QUINAZOLINE DERIVATIVES | Japan Energy Corporation (JP) | 2002-08-07 | — | — | EP | disclosed |