Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 4/20 | 0.42 |
| ▸ | PAK1 | Q13153 | 4/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7474878 | 0.88 | ACHE (0.42) | RETPAK1 | |
| SCHEMBL6338898 | 0.84 | RET (0.42) | RETPAK1HTR2AGRM2ABCB1 | |
| SCHEMBL7474781 | 0.80 | RET (0.50) | RET | |
| SCHEMBL6338906 | 0.79 | ABCB1 (0.41) | RETHTR2AGRM2ABCB1ABCG2 | |
| SCHEMBL6338894 | 0.79 | ABCB1 (0.41) | RETHTR2AGRM2ABCB1ABCG2 | |
| SCHEMBL5787693 | 0.78 | ABCB1 (0.47) | RETHTR2AABCB1ABCG2 | |
| SCHEMBL5787695 | 0.78 | ABCB1 (0.47) | RETHTR2AABCB1ABCG2 | |
| SCHEMBL7475213 | 0.78 | RET (0.43) | RET | |
| SCHEMBL7472918 | 0.76 | RET (0.54) | RETPAK1 | |
| SCHEMBL6333058 | 0.76 | PAK1 (0.39) | RETPAK1HTR2AGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212318-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | Boehringer Ingelheim Pharma KG (DE) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001016130-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-03-08 | — | — | WO | disclosed |