Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7476209 | 0.93 | NOTUM (0.38) | MAPK8PLA2G2AALDH1A1MAPTLMNA | |
| SCHEMBL7477529 | 0.81 | LMNA (0.31) | ALDH1A1MAPTLMNA | |
| SCHEMBL5237222 | 0.81 | LMNA (0.31) | ALDH1A1MAPTLMNA | |
| SCHEMBL5237232 | 0.81 | LMNA (0.31) | ALDH1A1MAPTLMNA | |
| SCHEMBL7482378 | 0.74 | ALDH1A1 (0.37) | ALDH1A1KMT2ACYP3A4TSHRKDM4E | |
| SCHEMBL7475018 | 0.74 | KDM4E (0.32) | ALDH1A1CYP3A4KDM4EMAPTLMNA | |
| SCHEMBL7479670 | 0.74 | MEN1 (0.36) | ALDH1A1KMT2ACYP3A4KDM4EMAPT | |
| SCHEMBL7478519 | 0.73 | ALDH1A1 (0.33) | ALDH1A1MAPTLMNA | |
| SCHEMBL7474346 | 0.73 | NPC1 (0.32) | ALDH1A1KMT2ACYP3A4MAPTLMNA | |
| SCHEMBL7478089 | 0.73 | KDM4E (0.32) | ALDH1A1KDM4EMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0742218-B1 | PYRROLOPYRIDAZINE DERIVATIVE | SANKYO CO (JP) | 2002-12-04 | — | — | EP | disclosed |
| US-6063782-A | Pyrrolopyridazine derivatives | SANKYO COMPANY, LIMITED (JP) | 2000-05-16 | — | — | US | disclosed |
| EP-0742218-A1 | PYRROLOPYRIDAZINE DERIVATIVE | SANKYO COMPANY LIMITED (JP) | 1996-11-13 | — | — | EP | disclosed |