Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 14/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.45 |
| ▸ | RECQL | P46063 | 3/20 | 0.45 |
| ▸ | CLK1 | P49759 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7468292 | 0.97 | LMNA (0.46) | LMNAMAPK1MAPTNPC1PKM | |
| SCHEMBL7462496 | 0.91 | WDR5 (0.40) | LMNAMAPK1MAPTNPC1PKM | |
| SCHEMBL7459991 | 0.90 | LMNA (0.52) | LMNAMAPK1MAPTNPC1PKM | |
| SCHEMBL7476400 | 0.88 | MAPT (0.41) | LMNAMAPK1MAPTNPC1PKM | |
| SCHEMBL7468826 | 0.85 | EGFR (0.56) | LMNAMAPK1MAPTALDH1A1TSHR | |
| SCHEMBL7468278 | 0.84 | ALDH1A1 (0.56) | LMNAMAPK1MAPTNPC1PKM | |
| SCHEMBL7469783 | 0.83 | ALDH1A1 (0.48) | LMNAMAPK1MAPTDYRK1AALDH1A1 | |
| SCHEMBL7475684 | 0.83 | EGFR (0.53) | LMNAMAPTALDH1A1EGFRKMT2A | |
| SCHEMBL7469725 | 0.82 | ALDH1A1 (0.50) | MAPK1MAPTALDH1A1EGFRHPGD | |
| SCHEMBL7470206 | 0.82 | EGFR (0.52) | LMNAMAPTALDH1A1CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229025-A1 | NOVEL QUINAZOLINE DERIVATIVES | Japan Energy Corporation (JP) | 2002-08-07 | — | — | EP | disclosed |