Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 9/20 | 0.38 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | F7 | P08709 | 1/20 | 0.35 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.34 |
| ▸ | ESRRG | P62508 | 1/20 | 0.34 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL746610 | 0.95 | TP53 (0.42) | TP53MAPTLMNALPAR1SLC13A5 | |
| SCHEMBL749589 | 0.93 | MAPT (0.48) | TP53MAPTSLC13A5NR1H4 | |
| SCHEMBL745473 | 0.88 | KMT2A (0.44) | MAPTLPAR1SLC13A5LPAR5ESRRG | |
| SCHEMBL748461 | 0.87 | ESRRG (0.46) | TP53MAPTLMNASLC13A5ESRRG | |
| SCHEMBL747101 | 0.87 | F2 (0.39) | TP53MAPTLMNALPAR1SLC13A5 | |
| SCHEMBL747114 | 0.86 | C5AR1 (0.41) | LMNALPAR1SLC13A5LPAR5ESRRG | |
| SCHEMBL747130 | 0.86 | SLC13A5 (0.37) | TP53MAPTLMNALPAR1SLC13A5 | |
| SCHEMBL748780 | 0.86 | TP53 (0.35) | TP53MAPTSLC13A5F2F10 | |
| SCHEMBL748533 | 0.86 | ESRRG (0.37) | TP53MAPTLMNASLC13A5ESRRG | |
| SCHEMBL748554 | 0.86 | LPAR1 (0.36) | TP53MAPTLMNALPAR1SLC13A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022217-B2 | Compounds suitable as modulators of HDL | CADILA HEALTHCARE LIMITED (IN) | 2011-09-20 | — | — | US | claimed |
| EP-2049493-B1 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LTD (IN) | 2012-03-21 | — | — | EP | disclosed |
| US-8022217-B2 | Compounds suitable as modulators of HDL | CADILA HEALTHCARE LIMITED (IN) | 2011-09-20 | — | — | US | disclosed |