Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL746610 | 0.93 | TP53 (0.42) | MAPTTP53SLC13A5SRCPKM | |
| SCHEMBL747640 | 0.93 | TP53 (0.41) | MAPTTP53SLC13A5NR1H4 | |
| SCHEMBL748532 | 0.87 | RIPK1 (0.37) | MAPTTP53PTGER2NR1H4PTGES | |
| SCHEMBL745473 | 0.85 | KMT2A (0.44) | MAPTSLC13A5MEN1KMT2ANR1H4 | |
| SCHEMBL748554 | 0.85 | LPAR1 (0.36) | MAPTTP53SLC13A5PTGER2KMT2A | |
| SCHEMBL748780 | 0.85 | TP53 (0.35) | MAPTTP53SLC13A5MEN1KMT2A | |
| SCHEMBL748461 | 0.85 | ESRRG (0.46) | MAPTTP53SLC13A5PKMMEN1 | |
| SCHEMBL747101 | 0.85 | F2 (0.39) | MAPTTP53SLC13A5SRCPKM | |
| SCHEMBL749665 | 0.84 | MAPT (0.42) | MAPTTP53SLC13A5SRCPTGER2 | |
| SCHEMBL747130 | 0.84 | SLC13A5 (0.37) | MAPTTP53SLC13A5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049493-B1 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LTD (IN) | 2012-03-21 | — | — | EP | claimed |
| US-8022217-B2 | Compounds suitable as modulators of HDL | CADILA HEALTHCARE LIMITED (IN) | 2011-09-20 | — | — | US | claimed |
| EP-2049493-B1 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LTD (IN) | 2012-03-21 | — | — | EP | disclosed |
| US-8022217-B2 | Compounds suitable as modulators of HDL | CADILA HEALTHCARE LIMITED (IN) | 2011-09-20 | — | — | US | disclosed |