Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 7/20 | 0.36 |
| ▸ | LPAR5 | Q9H1C0 | 6/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL749530 | 0.89 | NR1I2 (0.45) | SLC13A5KMT2ANR1I2LMNAADRA2A | |
| SCHEMBL746610 | 0.89 | TP53 (0.42) | LPAR1LPAR5TP53MAPTSLC13A5 | |
| SCHEMBL745473 | 0.88 | KMT2A (0.44) | LPAR1LPAR5MAPTSLC13A5KMT2A | |
| SCHEMBL748780 | 0.88 | TP53 (0.35) | TP53MAPTSLC13A5KMT2AKDM4E | |
| SCHEMBL747640 | 0.86 | TP53 (0.41) | LPAR1LPAR5TP53MAPTSLC13A5 | |
| SCHEMBL748461 | 0.86 | ESRRG (0.46) | TP53MAPTSLC13A5KMT2ALMNA | |
| SCHEMBL748241 | 0.86 | LPAR1 (0.36) | LPAR1LPAR5TP53MAPTADORA2A | |
| SCHEMBL749589 | 0.85 | MAPT (0.48) | TP53MAPTSLC13A5KMT2AALDH1A1 | |
| SCHEMBL748509 | 0.85 | LPAR1 (0.43) | LPAR1LPAR5TP53MAPTSLC13A5 | |
| SCHEMBL747130 | 0.85 | SLC13A5 (0.37) | LPAR1LPAR5TP53MAPTSLC13A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049493-B1 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LTD (IN) | 2012-03-21 | — | — | EP | claimed |
| US-8022217-B2 | Compounds suitable as modulators of HDL | CADILA HEALTHCARE LIMITED (IN) | 2011-09-20 | — | — | US | claimed |
| EP-2049493-B1 | COMPOUNDS SUITABLE AS MODULATORS OF HDL | CADILA HEALTHCARE LTD (IN) | 2012-03-21 | — | — | EP | disclosed |
| US-8022217-B2 | Compounds suitable as modulators of HDL | CADILA HEALTHCARE LIMITED (IN) | 2011-09-20 | — | — | US | disclosed |