Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8643594 | 1.00 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2HIF1ATDP1MAPK1 | |
| SCHEMBL4550673 | 1.00 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2HIF1ATDP1MAPK1 | |
| Hydrochloric Acid SCHEMBL11265034 | 0.98 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2HIF1ATDP1MAPK1 | |
| SCHEMBL11265025 | 0.88 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2HIF1ATDP1MAPK1 | |
| SCHEMBL28362146 | 0.88 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2HIF1ATDP1MAPK1 | |
| SCHEMBL7440964 | 0.88 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2HIF1ATDP1MAPK1 | |
| SCHEMBL28366123 | 0.88 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2HIF1ATDP1MAPK1 | |
| SCHEMBL9073323 | 0.85 | SMN1; SMN2 (0.68) | ALDH1A1SMN1; SMN2HIF1ATDP1MAPK1 | |
| SCHEMBL7653623 | 0.85 | SMN1; SMN2 (0.53) | ALDH1A1SMN1; SMN2HIF1ATDP1MAPK1 | |
| SCHEMBL8706009 | 0.85 | SMN1; SMN2 (0.68) | ALDH1A1SMN1; SMN2HIF1ATDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436919-B1 | LOCAL ANESTHETICS THAT HAVE LONGER DURATION OF ACTION WHILE REDUCING UNDESIRED SIDE EFFECTS | THERAVANCE INC. | 2002-08-20 | — | — | US | disclosed |
| EP-1216242-A1 | MACROCYCLIC QUINAZOLINONES AND THEIR USE AS LOCAL ANESTHETICS | Advanced Medicine, Inc. (US) | 2002-06-26 | — | — | EP | disclosed |
| EP-1216243-A1 | QUINAZOLINONES AND ANALOGUES AND THEIR USE AS LOCAL ANESTHETICS | Advanced Medicine, Inc. (US) | 2002-06-26 | — | — | EP | disclosed |
| US-6355637-B1 | QUINAZOLONES FOR LOCAL ANESTHETICS | ADVANCED MEDICINE, INC. | 2002-03-12 | — | — | US | disclosed |
| WO-2001025234-A1 | QUINAZOLINONES AND ANALOGUES AND THEIR USE AS LOCAL ANESTHETICS | ADVANCED MEDICINE, INC. (US) | 2001-04-12 | — | — | WO | disclosed |
| WO-2001025235-A1 | MACROCYCLIC QUINAZOLINONES AND THEIR USE AS LOCAL ANESTHETICS | ADVANCED MEDICINE, INC. (US) | 2001-04-12 | — | — | WO | disclosed |