Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7476437 | 1.00 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2HIF1ATDP1MAPK1 | |
| SCHEMBL8643594 | 1.00 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2HIF1ATDP1MAPK1 | |
| Hydrochloric Acid SCHEMBL11265034 | 0.98 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2HIF1ATDP1MAPK1 | |
| SCHEMBL11265025 | 0.88 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2HIF1ATDP1MAPK1 | |
| SCHEMBL28362146 | 0.88 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2HIF1ATDP1MAPK1 | |
| SCHEMBL7440964 | 0.88 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2HIF1ATDP1MAPK1 | |
| SCHEMBL28366123 | 0.88 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2HIF1ATDP1MAPK1 | |
| SCHEMBL9073323 | 0.85 | SMN1; SMN2 (0.68) | ALDH1A1SMN1; SMN2HIF1ATDP1MAPK1 | |
| SCHEMBL7653623 | 0.85 | SMN1; SMN2 (0.53) | ALDH1A1SMN1; SMN2HIF1ATDP1MAPK1 | |
| SCHEMBL8706009 | 0.85 | SMN1; SMN2 (0.68) | ALDH1A1SMN1; SMN2HIF1ATDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101031569-B | Quinazolinones as human phosphatidylinositol 3-kinase delta inhibitors | ICOS CORP | 2011-06-22 | — | — | CN | disclosed |
| US-7612075-B2 | Substituted oxoazaheterocyclyl compounds | AVENTIS PHARMACEUTICALS INC. (US) | 2009-11-03 | — | — | US | disclosed |
| EP-1051176-B1 | SUBSTITUTED OXOAZAHETEROCYCLYL FACTOR Xa INHIBITORS | AVENTIS PHARMA INC (US) | 2006-11-22 | — | — | EP | disclosed |
| US-20040102450-A1 | Substituted oxoazaheterocyclyl compounds | AVENTIS PHARMACEUTICALS INC. (US) | 2004-05-27 | — | — | US | disclosed |
| CN-1420882-A | Substd. oxoazaheterocyclyl compounds | AVENTIS PHARM PROD INC (US) | 2003-05-28 | — | — | CN | disclosed |
| EP-1051176-A4 | SUBSTITUTED OXOAZAHETEROCYCLYL FACTOR Xa INHIBITORS | AVENTIS PHARM PROD INC (US) | 2002-06-12 | — | — | EP | disclosed |
| EP-1208097-A2 | SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS | Aventis Pharmaceuticals Inc. (US) | 2002-05-29 | — | — | EP | disclosed |
| CN-1078204-C | Amino acid amide derivative, agrohorticultural bactericide, and production process | KUMIAI CHEMICAL INDUSTRY CO (JP) | 2002-01-23 | — | — | CN | disclosed |
| EP-1079821-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2001-08-29 | — | — | EP | disclosed |
| CN-1291892-A | Substituted oxoazaheterocyclyl factor Xa inhibitors | AWENTIS PHARMACEUTICAL INC (US) | 2001-04-18 | — | — | CN | disclosed |
| WO-1999037304-A1 | SUBSTITUTED OXOAZAHETEROCYCLYL FACTOR Xa INHIBITORS | AVENTIS PHARMACEUTICALS PRODUCTS INC. (US) | 1999-07-29 | — | — | WO | disclosed |
| US-5726185-A | BINDING OF ADHESIVE PROTEINS TO BLOOD PLATELET AGGREGATION AND CELL TO CELL ADHESION | HOFFMANN-LA ROCHE INC. (US) | 1998-03-10 | — | — | US | disclosed |
| WO-1997016433-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-05-09 | — | — | WO | disclosed |
| CN-1108863-A | Amino acid amide derivative, agrohorticultural bactericide, and production process | KUMIAI CHEMICAL INDUSTRY CO (JP) | 1995-09-20 | — | — | CN | disclosed |
| WO-1995022330-A1 | ANTIVIRAL AGENTS | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 1995-08-24 | — | — | WO | disclosed |
| US-4299767-A | ANTIALDOSTERONES, HYPOTENSIVE AGENTS, TREATMENT OF HEART AND LEVER DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1981-11-10 | — | — | US | disclosed |
| US-4296031-A | ALDOSTERONE ANTAGONIST | HOFFMANN-LA ROCHE INC. (US) | 1981-10-20 | — | — | US | disclosed |
| US-4294758-A | ANTICHOLESTEROL AGENTS, CARDIOVASCULAR DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1981-10-13 | — | — | US | disclosed |
| US-4281188-A | ANTIALDOSTERONES | HOFFMANN-LA ROCHE INC. (US) | 1981-07-28 | — | — | US | disclosed |
| US-4251443-A | ALDOSTERONE ANTAGONISTS; PREVENTION OF HEART FAILURE, HEPATIC ASCITES, ALDOSTERONISM, HYPERTENSION | HOFFMANN-LA ROCHE INC. (US) | 1981-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102450-A1 | Substituted oxoazaheterocyclyl compounds | F13B, F9, F11 | ALDH1A1 3776/4885SMN1; SMN2 4142/4885HIF1A 2572/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.