Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALKBH1 | Q13686 | 2/20 | 0.36 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | GPR183 | P32249 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7410510 | 0.76 | TSHR (0.35) | P4HTMLMNAL3MBTL1S1PR1S1PR5 | |
| SCHEMBL7414435 | 0.76 | TSHR (0.35) | P4HTMLMNAL3MBTL1S1PR1S1PR5 | |
| SCHEMBL17878844 | 0.72 | PDGFRB (0.50) | ALKBH1P4HTMLMNAL3MBTL1GRM5 | |
| SCHEMBL27306803 | 0.68 | ALDH1A1 (0.49) | LMNAL3MBTL1 | |
| SCHEMBL11063207 | 0.66 | ALDH1A1 (0.50) | LMNAL3MBTL1 | |
| SCHEMBL7414580 | 0.65 | TSHR (0.35) | LMNAL3MBTL1 | |
| SCHEMBL24534624 | 0.65 | ALDH1A1 (0.49) | LMNAL3MBTL1CHRNB2CHRNA4HRH3 | |
| SCHEMBL15898019 | 0.65 | ALDH1A1 (0.58) | LMNAL3MBTL1 | |
| SCHEMBL10946417 | 0.65 | ALDH1A1 (0.49) | LMNAL3MBTL1CHRNB2CHRNA4HRH3 | |
| SCHEMBL25948326 | 0.65 | ALDH1A1 (0.49) | LMNAL3MBTL1CHRNB2CHRNA4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0950057-B1 | 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS | ABBOTT LAB (US) | 2002-11-13 | — | — | EP | disclosed |
| US-6403575-B1 | ANTI-INFLAMMATORIES | ABBOTT LABORATORIES | 2002-06-11 | — | — | US | disclosed |
| US-6133253-A | NEURONAL CELL DEATH PREVENTORS AND ANTI-INFLAMMATORIES | ABBOTT LABORATORIES (US) | 2000-10-17 | — | — | US | disclosed |