Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 10/20 | 0.59 |
| ▸ | DRD2 | P14416 | 4/20 | 0.57 |
| ▸ | DRD3 | P35462 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MMP3 | P08254 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7464080 | 0.91 | DRD4 (0.55) | DRD4DRD2DRD3ALDH1A1LMNA | |
| SCHEMBL7470932 | 0.88 | HRH3 (0.49) | DRD4DRD2MAPTMMP3 | |
| SCHEMBL7470302 | 0.86 | MEN1 (0.60) | DRD4DRD2DRD3ALDH1A1LMNA | |
| SCHEMBL7474955 | 0.85 | ALDH1A1 (0.66) | DRD4DRD2DRD3ALDH1A1LMNA | |
| SCHEMBL7474472 | 0.80 | S1PR1 (0.46) | DRD4DRD2MMP3 | |
| SCHEMBL3891373 | 0.80 | ALDH1A1 (0.53) | DRD4DRD3ALDH1A1LMNAGAA | |
| SCHEMBL6243928 | 0.79 | ALDH1A1 (0.65) | DRD4DRD2DRD3ALDH1A1LMNA | |
| SCHEMBL3903652 | 0.79 | DRD4 (0.54) | DRD4DRD2DRD3ALDH1A1LMNA | |
| SCHEMBL22409694 | 0.77 | ALDH1A1 (0.55) | DRD4DRD2DRD3ALDH1A1LMNA | |
| SCHEMBL6263206 | 0.77 | ALDH1A1 (0.57) | DRD4ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757986-B1 | Arylpiperidine and arylpiperazine derivatives and drugs containing the same | SUNTORY LTD (JP) | 2002-06-12 | — | — | EP | disclosed |
| US-5723475-A | Arylpiperidine and arylpiperazine derivatives and medicament containing the same | SUNTORY LIMITED (JP) | 1998-03-03 | — | — | US | disclosed |
| EP-0757986-A1 | ARYLPIPERIDINE AND ARYLPIPERAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SUNTORY LIMITED (JP) | 1997-02-12 | — | — | EP | disclosed |