Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 5/20 | 0.52 |
| ▸ | DRD4 | P21917 | 4/20 | 0.52 |
| ▸ | DRD3 | P35462 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7477194 | 0.86 | DRD4 (0.59) | MEN1KMT2ADRD2DRD4DRD3 | |
| SCHEMBL7474955 | 0.82 | ALDH1A1 (0.66) | MEN1KMT2ADRD2DRD4DRD3 | |
| SCHEMBL7464080 | 0.81 | DRD4 (0.55) | MEN1KMT2ADRD2DRD4DRD3 | |
| SCHEMBL9843921 | 0.80 | KMT2A (0.53) | MEN1KMT2ATDP1DRD2DRD4 | |
| SCHEMBL9843914 | 0.76 | KMT2A (0.51) | MEN1KMT2ATDP1DRD2DRD4 | |
| SCHEMBL7470932 | 0.75 | HRH3 (0.49) | DRD2DRD4MMP3MAPT | |
| SCHEMBL6161142 | 0.74 | SIGMAR1 (0.58) | KMT2ALMNAGAAMMP3ALDH1A1 | |
| SCHEMBL7475866 | 0.74 | MMP3 (0.51) | MEN1KMT2ADRD2DRD4DRD3 | |
| SCHEMBL27477245 | 0.73 | SLC18A3 (0.57) | DRD2MMP3 | |
| SCHEMBL4010002 | 0.72 | DRD4 (0.75) | MEN1KMT2ATDP1DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757986-B1 | Arylpiperidine and arylpiperazine derivatives and drugs containing the same | SUNTORY LTD (JP) | 2002-06-12 | — | — | EP | disclosed |
| US-5723475-A | Arylpiperidine and arylpiperazine derivatives and medicament containing the same | SUNTORY LIMITED (JP) | 1998-03-03 | — | — | US | disclosed |
| EP-0757986-A1 | ARYLPIPERIDINE AND ARYLPIPERAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SUNTORY LIMITED (JP) | 1997-02-12 | — | — | EP | disclosed |