Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 6/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7477202 | 1.00 | MAPT (0.43) | MAPTKDM4ENPSR1SMN1; SMN2RAB9A | |
| SCHEMBL7478519 | 0.81 | ALDH1A1 (0.33) | MAPTNPSR1SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL27352497 | 0.80 | ALDH1A1 (0.56) | MAPTNPSR1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7478131 | 0.80 | ALDH1A1 (0.32) | MAPTNPSR1SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL7478235 | 0.75 | ADORA2B (0.31) | MEN1KMT2A | |
| SCHEMBL7483009 | 0.75 | ALDH1A1 (0.34) | MAPTKDM4ENPSR1ALDH1A1LMNA | |
| SCHEMBL7475018 | 0.71 | KDM4E (0.32) | MAPTKDM4ENPSR1RAB9AL3MBTL1 | |
| SCHEMBL7474346 | 0.70 | NPC1 (0.32) | MAPTNPSR1RAB9ANPC1ALDH1A1 | |
| SCHEMBL7478089 | 0.70 | KDM4E (0.32) | MAPTKDM4ENPSR1L3MBTL1ALDH1A1 | |
| SCHEMBL5237232 | 0.68 | LMNA (0.31) | MAPTNPSR1ALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0742218-B1 | PYRROLOPYRIDAZINE DERIVATIVE | SANKYO CO (JP) | 2002-12-04 | — | — | EP | disclosed |
| US-6063782-A | Pyrrolopyridazine derivatives | SANKYO COMPANY, LIMITED (JP) | 2000-05-16 | — | — | US | disclosed |
| EP-0742218-A1 | PYRROLOPYRIDAZINE DERIVATIVE | SANKYO COMPANY LIMITED (JP) | 1996-11-13 | — | — | EP | disclosed |