Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2439447 | 0.96 | CTSK (0.32) | CTSKNR1H2TDP1HPGD | |
| SCHEMBL1296518 | 0.94 | HPGD (0.33) | CTSKNR1H2TDP1HPGD | |
| SCHEMBL585129 | 0.82 | CHRM2 (0.40) | NR1H2HPGD | |
| SCHEMBL7603453 | 0.78 | EPHX1 (0.31) | CTSK | |
| SCHEMBL4040718 | 0.78 | NR1H2 (0.30) | NR1H2TDP1 | |
| SCHEMBL9178020 | 0.77 | BBOX1 (0.32) | CTSK | |
| SCHEMBL6701925 | 0.77 | EPHX1 (0.30) | CTSK | |
| SCHEMBL1786719 | 0.77 | EPHX1 (0.30) | CTSK | |
| SCHEMBL5797913 | 0.76 | KDM4E (0.31) | — | |
| SCHEMBL28868020 | 0.72 | DGAT1 (0.32) | CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0950057-B1 | 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS | ABBOTT LAB (US) | 2002-11-13 | — | — | EP | disclosed |
| EP-1242370-A1 | SYNTHESIS OF CHIRAL 2-AZETIDINEMETHANOL COMPOUNDS | ABBOTT LABORATORIES (US) | 2002-09-25 | — | — | EP | disclosed |
| US-6437138-B1 | 5-BROMO-6-CHLORO-3-(2-(S)-AZETIDINYL OR PYRROLIDINYL-METHOXY) PYRIDINE INTERMEDIATES FOR THE 5-SUBSTITUTED COMPOUNDS WHICH ARE POTENT LIGANDS AT NEURONAL NICOTINIC CHOLINERGIC CHANNEL RECEPTORS, NEUROTRANSMITTER CONTROLLING AGENTS | ABBOTT LABORATORIES | 2002-08-20 | — | — | US | disclosed |
| US-6403575-B1 | ANTI-INFLAMMATORIES | ABBOTT LABORATORIES | 2002-06-11 | — | — | US | disclosed |
| WO-2001046135-A1 | SYNTHESIS OF CHIRAL 2-AZETIDINEMETHANOL COMPOUNDS | ABBOTT LABORATORIES (US) | 2001-06-28 | — | — | WO | disclosed |
| US-6133253-A | NEURONAL CELL DEATH PREVENTORS AND ANTI-INFLAMMATORIES | ABBOTT LABORATORIES (US) | 2000-10-17 | — | — | US | disclosed |
| US-6127386-A | STIMULANTS, NEUROTRANSMITTERS, CHOLINERGIC AGENTS | ABBOTT LABORATORIES (US) | 2000-10-03 | — | — | US | disclosed |
| US-6124474-A | Synthesis of chiral 2-azetidinemethanol compounds | ABBOTT LABORATORIES (US) | 2000-09-26 | — | — | US | disclosed |
| EP-0950057-A1 | 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS | Abbott Laboratories (US) | 1999-10-20 | — | — | EP | disclosed |
| WO-1998025920-A1 | 3-PYRIDYL ENANTIOMERS AND THEIR USE AS ANALGESICS | ABBOTT LABORATORIES (US) | 1998-06-18 | — | — | WO | disclosed |