SCHEMBL7477308

SCHEMBL7477308

O=C(O)c1cccc(CCc2nc(C3CCC3)cs2)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM2 Q14416 1/20 0.43
GRM3 Q14832 1/20 0.43
KMO O15229 1/20 0.42
MRGPRX4 Q96LA9 2/20 0.40
ALOX5AP P20292 1/20 0.40
FEN1 P39748 1/20 0.40
ENPP2 Q13822 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
HIF1A Q16665 1/20 0.40
FOLH1 Q04609 1/20 0.40
HDAC1 Q13547 2/20 0.39
HDAC6 Q9UBN7 2/20 0.39
ACMSD Q8TDX5 2/20 0.39
DAO P14920 1/20 0.39
EPHX1 P07099 1/20 0.38
CCR5 P51681 1/20 0.38
ECE1 P42892 1/20 0.38
PTGER1 P34995 1/20 0.37
PTGER4 P35408 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5708669 0.81 KDM4E (0.38) HDAC1HDAC6CCR5ECE1SMN1; SMN2
SCHEMBL7472699 0.80 NR4A2 (0.48) MRGPRX4CPT2CPT1ACPT1BHTT
SCHEMBL5708660 0.78 DRD2 (0.40) ALOX5APFEN1CYP2D6HDAC1HDAC6
SCHEMBL7473175 0.77 NR4A2 (0.48) KMOMRGPRX4CPT2CPT1ACPT1B
SCHEMBL7471030 0.76 NR4A2 (0.47) KMOMRGPRX4CPT2CPT1ACPT1B
SCHEMBL5585254 0.75 HDAC3 (0.48) HDAC6
SCHEMBL7472058 0.75 MEN1 (0.46) GRM2GRM3MRGPRX4ENPP2FOLH1
SCHEMBL7467443 0.74 NR4A2 (0.50) MRGPRX4CPT2CPT1ACPT1B
SCHEMBL8653482 0.73 HDAC1 (0.30) HDAC1HDAC6
SCHEMBL5908275 0.73 METTL3 (0.33) HDAC1HDAC6CCR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1107059-C Azole deriv. YAMANOUCHI PHARMA CO LTD (JP) 2003-04-30 CN disclosed
EP-0786457-B1 AZOLE DERIVATIVES YAMANOUCHI PHARMA CO LTD (JP) 2002-05-29 EP disclosed
US-5981559-A USEFUL IN PREVENTING OR TREATING ALLERGIC DISEASES, ISCHEMIC HEART DISEASES OR ISCHEMIC BRAIN DISEASES YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1999-11-09 US disclosed
CN-1160397-A Azole deriv. YAMANOUCHI PHARMA CO LTD (JP) 1997-09-24 CN disclosed
EP-0786457-A1 AZOLE DERIVATIVE YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1997-07-30 EP disclosed