Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.64 |
| ▸ | MEN1 | O00255 | 5/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | ABL1 | P00519 | 6/20 | 0.52 |
| ▸ | SRC | P12931 | 6/20 | 0.52 |
| ▸ | POLB | P06746 | 5/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7482874 | 0.92 | LMNA (0.62) | KMT2AMEN1LMNAGAAMAPT | |
| SCHEMBL7481013 | 0.84 | MAPT (0.63) | KMT2AMEN1LMNAGAAMAPT | |
| SCHEMBL7479841 | 0.82 | NTRK1 (0.60) | KMT2AMEN1LMNAGAAMAPT | |
| SCHEMBL7487945 | 0.82 | BLM (0.61) | KMT2AMEN1LMNAGAAMAPT | |
| SCHEMBL7488953 | 0.78 | KMT2A (0.57) | KMT2AMEN1LMNAGAAMAPT | |
| SCHEMBL10667217 | 0.74 | POLB (0.53) | KMT2AMEN1LMNAGAAMAPT | |
| SCHEMBL7476339 | 0.72 | MAPT (0.67) | KMT2AMEN1LMNAGAAMAPT | |
| SCHEMBL11623690 | 0.70 | ABL1 (0.74) | KMT2AMEN1LMNAGAAMAPT | |
| SCHEMBL3467894 | 0.70 | MEN1 (0.62) | KMT2AMEN1LMNAGAAMAPT | |
| SCHEMBL7429049 | 0.70 | NTRK1 (0.62) | KMT2AMEN1LMNAGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999020617-A1 | ANTIINFLAMMATORY THIADIAZOLYL UREAS WHICH ACT AS LFA-1 AND MAC-1 INHIBITORS | ACTIVE BIOTECH AB (SE) | 1999-04-29 | — | — | WO | claimed |
| WO-1999020617-A1 | ANTIINFLAMMATORY THIADIAZOLYL UREAS WHICH ACT AS LFA-1 AND MAC-1 INHIBITORS | ACTIVE BIOTECH AB (SE) | 1999-04-29 | — | — | WO | disclosed |