Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.57 |
| ▸ | POLB | P06746 | 5/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 3/20 | 0.50 |
| ▸ | SRC | P12931 | 3/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.48 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.48 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7483795 | 0.90 | MEN1 (0.65) | KMT2APOLBMEN1GAALMNA | |
| SCHEMBL7480640 | 0.85 | MEN1 (0.59) | KMT2AMEN1GAALMNAMAPT | |
| SCHEMBL7479597 | 0.83 | GLS (0.55) | KMT2APOLBMEN1GAALMNA | |
| SCHEMBL7483978 | 0.82 | ABL1 (0.62) | KMT2AMEN1GAALMNAMAPT | |
| SCHEMBL7423143 | 0.79 | MEN1 (0.62) | KMT2APOLBMEN1GAALMNA | |
| SCHEMBL7484054 | 0.79 | LMNA (0.61) | KMT2APOLBMEN1GAALMNA | |
| SCHEMBL7477400 | 0.78 | KMT2A (0.64) | KMT2APOLBMEN1GAALMNA | |
| SCHEMBL7483438 | 0.78 | RAB9A (0.54) | KMT2APOLBMEN1GAALMNA | |
| SCHEMBL7481013 | 0.77 | MAPT (0.63) | KMT2APOLBMEN1GAALMNA | |
| SCHEMBL7482874 | 0.77 | LMNA (0.62) | KMT2APOLBMEN1GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999020617-A1 | ANTIINFLAMMATORY THIADIAZOLYL UREAS WHICH ACT AS LFA-1 AND MAC-1 INHIBITORS | ACTIVE BIOTECH AB (SE) | 1999-04-29 | — | — | WO | claimed |
| WO-1999020617-A1 | ANTIINFLAMMATORY THIADIAZOLYL UREAS WHICH ACT AS LFA-1 AND MAC-1 INHIBITORS | ACTIVE BIOTECH AB (SE) | 1999-04-29 | — | — | WO | disclosed |