Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | CTSB | P07858 | 2/20 | 0.41 |
| ▸ | CTSH | P09668 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7471291 | 0.82 | CTSB (0.38) | ADRB2PARP1CTSBCTSHKDM4E | |
| SCHEMBL2004140 | 0.81 | GRIN2D (0.40) | ADRB2PARP1KDM4EALDH1A1MEN1 | |
| SCHEMBL7483015 | 0.81 | MEN1 (0.54) | PARP1KDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL4812782 | 0.80 | PIN1 (0.37) | ADRB2CTSBKDM4EGPR35ALDH1A1 | |
| SCHEMBL6657865 | 0.75 | ADRB2 (0.58) | ADRB2PARP1KDM4ECYP1A2CYP2D6 | |
| SCHEMBL6509697 | 0.75 | ADRB2 (0.58) | ADRB2PARP1KDM4ECYP1A2CYP2D6 | |
| SCHEMBL7477486 | 0.74 | ALDH1A1 (0.40) | CTSBCTSHKDM4EGPR35MCL1 | |
| SCHEMBL6142554 | 0.73 | TDP1 (0.46) | ADRB2PARP1CTSBCTSHALDH1A1 | |
| SCHEMBL2672168 | 0.73 | CTSB (0.58) | PARP1CTSBCTSHKDM4EGPR35 | |
| SCHEMBL6506668 | 0.73 | ADRB2 (0.55) | ADRB2PARP1KDM4ECYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1110305-C | Naphthyl-substituted benzimidazole derivatives as anticoagulants | BERLEX LAB (US) | 2003-06-04 | — | — | CN | disclosed |
| EP-0865281-B1 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LAB (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-0865281-A4 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LAB (US) | 1999-07-28 | — | — | EP | disclosed |
| CN-1209062-A | Naphthyl-substituted benzimidazole derivatives as anticoagulants | BERLEX LAB (US) | 1999-02-24 | — | — | CN | disclosed |
| US-5849759-A | Naphthyl-substituted benzimidazole derivatives as anti-coagulants | BERLEX LABORATORIES, INC. (US) | 1998-12-15 | — | — | US | disclosed |
| EP-0865281-A1 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LABORATORIES, INC. (US) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997021437-A1 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LABORATORIES, INC. (DE) | 1997-06-19 | — | — | WO | disclosed |