Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 9/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | ANPEP | P15144 | 2/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7481106 | 0.98 | ESR1 (0.45) | ESR1ESR2CYP1A2LMNAANPEP | |
| SCHEMBL7481797 | 0.86 | STAT3 (0.52) | ESR1ESR2CYP1A2LMNAAPP | |
| SCHEMBL7486935 | 0.80 | CASP6 (0.51) | CYP1A2LMNATDP1MAOAMAOB | |
| Hydrochloric Acid SCHEMBL7483427 | 0.80 | CYP1A2 (0.45) | CYP1A2LMNAALDH1A1MAPK1STAT3 | |
| SCHEMBL7485009 | 0.80 | CYP1A2 (0.71) | CYP1A2LMNAALDH1A1GAAMAPT | |
| SCHEMBL7481564 | 0.78 | STAT3 (0.45) | ESR1ESR2LMNAANPEPDPP4 | |
| SCHEMBL7479666 | 0.78 | APP (0.46) | CYP1A2LMNAAPPALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL7485356 | 0.77 | APP (0.45) | CYP1A2LMNAAPPALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL7475918 | 0.76 | STAT3 (0.43) | ESR1ESR2LMNAANPEPDPP4 | |
| Hydrochloric Acid SCHEMBL7475915 | 0.76 | STAT3 (0.43) | ESR1ESR2LMNAANPEPDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0950056-B1 | N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS | AVENTIS PHARMA INC (US) | 2002-09-18 | — | — | EP | claimed |
| EP-0950056-A2 | N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS | HOECHST MARION ROUSSEL, INC. (US) | 1999-10-20 | — | — | EP | claimed |
| WO-1998029407-A2 | N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION | HOECHST MARION ROUSSEL, INC. (US) | 1998-07-09 | — | — | WO | claimed |