Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TYK2 | P29597 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7485356 | 0.99 | APP (0.45) | APPCYP19A1POLBCYP1A2ALDH1A1 | |
| SCHEMBL7476799 | 0.82 | ALDH1A1 (0.51) | CYP19A1CYP1A2ALDH1A1TYK2MAPT | |
| Hydrochloric Acid SCHEMBL8418434 | 0.80 | ALDH1A1 (0.49) | CYP19A1CYP1A2ALDH1A1TYK2MAPT | |
| Hydrochloric Acid SCHEMBL8418433 | 0.80 | ALDH1A1 (0.49) | CYP19A1CYP1A2ALDH1A1TYK2MAPT | |
| Hydrochloric Acid SCHEMBL7482266 | 0.79 | ALDH1A1 (0.48) | CYP19A1CYP1A2ALDH1A1TYK2MAPT | |
| SCHEMBL7481797 | 0.79 | STAT3 (0.52) | APPPOLBCYP1A2ALDH1A1MAPT | |
| SCHEMBL7477593 | 0.78 | ESR1 (0.46) | APPCYP1A2ALDH1A1MAPTCA1 | |
| Hydrochloric Acid SCHEMBL7481106 | 0.77 | ESR1 (0.45) | APPCYP1A2ALDH1A1MAPTMAOB | |
| Hydrochloric Acid SCHEMBL7483427 | 0.77 | CYP1A2 (0.45) | CYP1A2ALDH1A1MAPTCA1CA2 | |
| SCHEMBL7485009 | 0.76 | CYP1A2 (0.71) | CYP1A2ALDH1A1MAPTCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0950056-B1 | N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS | AVENTIS PHARMA INC (US) | 2002-09-18 | — | — | EP | claimed |
| EP-0950056-A2 | N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS | HOECHST MARION ROUSSEL, INC. (US) | 1999-10-20 | — | — | EP | claimed |
| WO-1998029407-A2 | N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION | HOECHST MARION ROUSSEL, INC. (US) | 1998-07-09 | — | — | WO | claimed |
| EP-0950056-B1 | N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS | AVENTIS PHARMA INC (US) | 2002-09-18 | — | — | EP | disclosed |
| US-6004977-A | ANTIDEPRESSANTS, COGNITION ACTIVATORS, AND ALZHEIMER'S DISEASE TREATMENT | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0950056-A2 | N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS | HOECHST MARION ROUSSEL, INC. (US) | 1999-10-20 | — | — | EP | disclosed |
| WO-1998029407-A2 | N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION | HOECHST MARION ROUSSEL, INC. (US) | 1998-07-09 | — | — | WO | disclosed |