Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 2/20 | 0.51 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.38 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | ITGA1 | P56199 | 1/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | F3 | P13726 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7486935 | 0.84 | CASP6 (0.51) | CASP6LMNAKDM4ETDP1 | |
| SCHEMBL7487924 | 0.84 | CASP6 (0.51) | CASP6MEN1KMT2APARP1PARP10 | |
| SCHEMBL7476799 | 0.81 | ALDH1A1 (0.51) | CASP6TYK2MEN1KMT2ALMNA | |
| SCHEMBL7485422 | 0.81 | CASP6 (0.48) | CASP6JAK2JAK1TYK2PDCD1 | |
| Hydrochloric Acid SCHEMBL8418433 | 0.79 | ALDH1A1 (0.49) | CASP6TYK2MEN1KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL8418434 | 0.79 | ALDH1A1 (0.49) | CASP6TYK2MEN1KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL7482266 | 0.78 | ALDH1A1 (0.48) | CASP6TYK2MEN1KMT2ALMNA | |
| SCHEMBL13806860 | 0.78 | CASP6 (0.78) | CASP6MEN1KMT2AITGA1LMNA | |
| SCHEMBL8860253 | 0.70 | CASP6 (0.38) | CASP6MEN1KMT2A | |
| SCHEMBL9390048 | 0.69 | CASP6 (0.44) | CASP6MEN1KMT2AF7PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0950056-B1 | N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS | AVENTIS PHARMA INC (US) | 2002-09-18 | — | — | EP | claimed |
| EP-0950056-B1 | N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS | AVENTIS PHARMA INC (US) | 2002-09-18 | — | — | EP | disclosed |
| US-6004977-A | ANTIDEPRESSANTS, COGNITION ACTIVATORS, AND ALZHEIMER'S DISEASE TREATMENT | HOECHST MARION ROUSSEL, INC. (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0950056-A2 | N-(PYRIDINYLAMINO)ISOINDOLINES AND RELATED COMPOUNDS | HOECHST MARION ROUSSEL, INC. (US) | 1999-10-20 | — | — | EP | disclosed |
| WO-1998029407-A2 | N-(PYRIDINYLAMINO)ISOINDOLINES FOR TREATING ALZHEIMER'S AND DEPRESSION | HOECHST MARION ROUSSEL, INC. (US) | 1998-07-09 | — | — | WO | disclosed |